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许多细胞株的药物耐受性主要归因于mdr-1或MRP基因过分表达及其产物的作用,而在同一细胞株中它们的共表达还没有报道。本研究通过增加VP-16剂量,持续培养而建立了人小细胞肺癌H69/
The drug resistance of many cell lines is mainly attributed to the overexpression of mdr-1 or MRP genes and their products, and their co-expression in the same cell line has not been reported. In this study, human small cell lung cancer H69/ was established by increasing the dose of VP-16 and continuing to culture.