对人工发酵培育冬虫夏草进行急性和亚慢性毒性研究。大、小鼠经口ＬＤ＿（５０）均大于１０ｇ／ｋｇ体重，亚慢性毒性研究（９０ｄ喂养试验）３个实验组动物生长发育正常，在试验第４５ｄ与第９０ｄ所作血液常规、血液生化、脏体比及病理学检查，３个实验组绝大多数检测项目与对照组未见显著性差异，极个别检测项目有显著性差异，但其差异无实际意义。研究表明人工发酵培育冬虫夏草毒理学是安全的。 The acute and sub-chronic toxicity of Cordyceps sinensis was studied by artificial fermentation. The oral LD_(50) of mice and mice were all greater than 10 g/kg body weight. In the subchronic toxicity study (90 d feeding test), the animals in the 3 experimental groups had normal growth and development. Routine blood, blood biochemistry, and blood were made on the 45th and 90th days of the experiment. The body-to-body ratio and pathological examination showed that there was no significant difference between the majority of the test items in the three experimental groups and the control group, and there were significant differences among the very few test items, but the difference was not practical. Studies have shown that artificial fermentation of Cordyceps sinensis is safe.