论文部分内容阅读
最近的动物和人体试验研究表明,以分泌性IgA(S-IgA)抗体为特征的粘膜免疫系统含有特殊的淋巴样组织,环境中的抗原与之接触并被吸收,然后诱生B和T细胞应答。随后,特异性淋巴细胞离开并聚居于各种效应部位(如粘膜固有层和腺体)。这些应答由T细胞和细胞因子调节,并导致浆细胞分化和外分泌中产生S-IgA抗体。这一知识可成为一种实用的方法,用于疫苗构建并释放到粘膜诱导部位,在发生感染的粘膜表面激发宿主的保护性免疫应答。
Recent animal and human experimental studies have shown that the mucosal immune system, characterized by secreted IgA (S-IgA) antibodies, contains specific lymphoid tissues with which the antigen in the environment is contacted and absorbed and then B and T cells are induced answer. Subsequently, specific lymphocytes leave and colonize various effector sites (such as lamina propria and glands). These responses are regulated by T cells and cytokines and result in the production of S-IgA antibodies in plasma cell differentiation and exocrine. This knowledge can be a useful method for vaccine construction and delivery to mucosal inducible sites that stimulate the host’s protective immune response at the mucosal surface where infection occurs.