作者曾制备了一种“内影像”单克隆抗独特型抗体（抗-id）,模拟HBsAg的“a”决定簇激发抗体产生和T细胞增殖。以后又从抗-id重链超变区制取一段15个氨基酸的线性肽（2F10肽）。该肽虽然在定性上能模拟2F10抗体激发B和T细胞应答,但在定量上则不如2F10抗体有效。为了提高2F10肽的免疫原性,作者在赖氨酸骨架上合成2F10肽八聚 The authors have prepared an “internal image” monoclonal anti-idiotypic antibody (anti-id) that mimics the “a” determinant of HBsAg to stimulate antibody production and T cell proliferation. Later, a 15-amino acid linear peptide (2F10 peptide) was prepared from the anti-id heavy chain hypervariable region. The peptide, although qualitatively mimicking the 2F10 antibody to elicit B and T cell responses, is not as potent as the 2F10 antibody in terms of quantitation. To improve the immunogenicity of 2F10 peptide, the authors synthesized 2F10 peptide octakis