【摘 要】
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Six nonionic oligomeric manganese(Ⅱ) complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal rel
【出 处】
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Chemical Research in Chinese Universities
论文部分内容阅读
Six nonionic oligomeric manganese(Ⅱ) complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the Τ_1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn(Ⅱ) complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.
Six nonionic oligomeric manganese (II) complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute Toxicity test and the T_1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn (II) complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.
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