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研究地点:中国台湾地区台北市。目的:评价在抗结核病治疗过程中,抗结核药物处方的合理性。方法:通过核查结核病患者的病历,获得台北市2003年登记和治疗的全部患者的治疗方案,并与推荐的用药剂量进行比较。结果:共有24种不同的抗结核治疗方案在使用。在登记的1700例患者中,1096例患者(64.5%)有体质量记录;共有506例患者使用了3药组合的固定剂量复合制剂(FDC),其中374例(73.9%)的用药剂量符合要求,100例(19.8%)剂量过低,32例(6.3%)剂量过高;共有75例患者使用了2药组合的FDC,其中57例(76.0%)的用药剂量符合要求,15例(20.0%)剂量过低,3例(4.0%)剂量过高;共有481例患者使用了利福平,其中302例(62.8%)的用药剂量符合要求,152例(31.6%)剂量过低,27例(5.6%)剂量过高;共有451例患者使用了异烟肼,其中396例(87.8%)患者的用药剂量符合要求,29例(6.4%)剂量过低,26例(5.8%)剂量过高。结论:抗结核药物使用是标准化的,但尚需进一步完善。研究结果提示结核病防治规划有待加强。
Research Location: Taipei, Taiwan. Objective: To evaluate the rationality of anti-tuberculosis prescription in the anti-tuberculosis treatment. Methods: The treatment regimens of all patients registered and treated in Taipei in 2003 were obtained by checking the medical record of TB patients and compared with the recommended dosage. RESULTS: A total of 24 different anti-TB treatment regimens were in use. Of the 1,700 registered patients, 1096 patients (64.5%) had body mass recordings; a total of 506 patients received a fixed-dose combination of three (FDC) with a combination of 374 (73.9%) doses , 100 cases (19.8%) were overdosed and 32 cases (6.3%) were overdosed. A total of 75 patients used FDC in combination with 2 drugs, of which 57 cases (76.0% %), And 3 (4.0%) doses were too high. A total of 481 patients received rifampicin, 302 of them (62.8%) met the required dose, 152 (31.6% A total of 451 patients were treated with isoniazid, of which 396 (87.8%) had satisfactory doses, 29 (6.4%) had low dose, and 26 (5.8%) had dose Too high. Conclusion: The use of anti-TB drugs is standardized, but needs to be further improved. The results suggest that tuberculosis prevention and control programs need to be strengthened.