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全世界的临床医师和患儿家长都认为儿童疾病治疗中适合儿童的循证治疗指南、药物治疗的相关知识和可用的人力资源缺乏,这些问题在成人疾病治疗中早已解决。中国儿童的合理用药存在许多影响因素,本文着重阐述了部分亟待解决的问题,这些必然可以使中国儿童获得合理的循证治疗。目前,科研单位正致力于建立模型和模拟的研究计划来促进更广泛的适合儿童的和可替代的临床试验。新生儿、神经/精神健康、行为障碍,特别是“孤儿病”的创新治疗方法急需更深入的研究。中国的医学同行们有机会在未来参与或主导创造一个安全和完善的治疗系统,使患儿获得最准确的治疗。因此,优化治疗方法是儿科临床药理学家、所有儿科临床医师和药师的首要共同目标。但是,这些目标和计划必须获得患儿、监护人和家属的认可,最重要的是获得医药管理部门的认可。
Clinicians and parents around the world believe that evidence-based treatment guidelines for children in the treatment of childhood diseases, knowledge about medication and lack of available human resources have long been addressed in the treatment of adult diseases. There are many influencing factors for the rational use of Chinese children. This article focuses on some of the problems to be solved, which will inevitably enable Chinese children to receive evidence-based treatment. At present, research institutes are working to establish models and simulation research programs to promote a wider range of child-friendly and alternative clinical trials. Innovative treatments for newborns, neuropsychiatric disorders, behavioral disorders, and especially “orphan disease” are in urgent need of further research. Chinese medical colleagues have the opportunity to participate in or lead in the future to create a safe and comprehensive treatment system so that children receive the most accurate treatment. Therefore, optimizing the treatment is the primary common goal of pediatric clinical pharmacologists, all pediatric clinicians and pharmacists. However, these goals and plans must be endorsed by children, guardians and dependents, and most importantly, by the medical authorities.