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目的:探讨高频振荡通气(HFOV)在新生儿肺出血患者中的临床疗效。方法:采取随机的原则选取70例新生儿肺出血患者作分析研究,分为观察组与对照组各35例。观察组采取HFOV的措施,而对照组则使用常频通气(CV)的方案。在病程中观察与比较两组的各项临床指标,做出综合的分析与评价。结果:观察组患儿的肺出血时间、氧疗时间、上机时间及住院时间均显著小于对照组患儿;观察组与对照组在出现气胸、血糖异常、消化道出血、颅内出血及败血症这几个并发症方面差异无统计学意义(P>0.05);然而观察组患者在肾损害与呼吸机相关性肺炎(VAP)的发生率方面均小于对照组患者,差异有统计学意义(P<0.05);观察组死亡5例,对照组死亡13例,观察组病死率明显小于对照组,差异有统计学意义(P<0.05)。结论:HFOV能够明显减少新生儿肺出血患者的VAP与肾损害发生率,并一定程度上减少患者的病程、住院时间以及病死率。
Objective: To investigate the clinical efficacy of high frequency oscillatory ventilation (HFOV) in neonates with pulmonary hemorrhage. Methods: Randomly selected 70 cases of neonatal pulmonary hemorrhage patients for analysis, divided into observation group and control group of 35 cases. The observation group took HFOV, while the control group used the regimen of frequent ventilatory (CV). In the course of the disease observed and compared the two groups of clinical indicators, to make a comprehensive analysis and evaluation. Results: The pulmonary hemorrhage time, oxygen therapy time, on-machine time and hospital stay in observation group were significantly less than those in control group; pneumoconiosis, abnormal glucose, gastrointestinal bleeding, intracranial hemorrhage and septicemia were observed in observation group and control group There were no significant differences in several complications (P> 0.05). However, the incidence of renal injury and ventilator-associated pneumonia (VAP) in the observation group was significantly lower than that in the control group (P < 0.05). There were 5 deaths in the observation group and 13 deaths in the control group. The mortality in the observation group was significantly less than that in the control group (P <0.05). Conclusion: HFOV can significantly reduce the incidence of VAP and renal damage in neonates with pulmonary hemorrhage, and to a certain extent reduce the patient’s duration of illness, hospitalization and mortality.