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目的 探讨CD4 4 V6、C erbB 2、雌激素受体 (ER)、孕激素受体 (PR)的表达与乳腺癌临床病理生物学行为的关系及其临床意义 ,评价其各自在临床中的作用。方法 采用CD4 4 V6、C erbB 2、ER、PR单克隆抗体对 12 6例原发性乳腺癌组织进行SP免疫组织化学检测 ,并对检测结果进行统计学分析。结果 CD4 4 V6阳性表达率与患者年龄、肿瘤大小、腋淋巴结转移情况、TNM分期及组织学分级无显著相关性 ,而与组织学类型相关 ,单纯癌、硬癌和髓样癌阳性表达率明显高于黏液腺癌和浸润性小叶癌 ;C erbB 2阳性表达率与患者年龄、肿瘤大小、TNM分期、组织学分级及组织学类型无显著相关 ,而与腋淋巴结转移情况相关 ;ER和PR阳性表达率与患者年龄、肿瘤大小、腋淋巴结转移情况、TNM分期、组织学分级及组织学类型无相关性。结论 CD4 4 V6作为判断乳腺癌预后的指标不够理想 ,C erbB 2可作为判断乳腺癌预后的一个指标 ,ER和PR测定的意义在于指导临床治疗方案的选择。
Objective To investigate the relationship between the expression of CD4 4 V6, C erbB 2, estrogen receptor (ER) and progesterone receptor (PR) and the clinicopathological and biological behaviors of breast cancer and to evaluate their respective clinical roles . Methods The monoclonal antibodies against CD4 4 V6, C erbB 2, ER and PR were used to detect SP immunohistochemistry in 12 6 cases of primary breast cancer and the results were analyzed statistically. Results There was no significant correlation between the positive rate of CD4 4 V6 expression and the age, tumor size, axillary lymph node metastasis, TNM stage and histological grade. However, the positive rate of CD4 4 V6 expression correlated with the histological type, and the positive rates of simple carcinoma, hard carcinoma and medullary carcinoma were significantly Which was higher than that of mucinous adenocarcinoma and invasive lobular carcinoma. The positive rate of C erbB 2 was not associated with the age, tumor size, TNM stage, histological grade and histological type, but with axillary lymph node metastasis. The positive rate of ER and PR There was no correlation between the expression rate and patient’s age, tumor size, axillary lymph node metastasis, TNM stage, histological grade and histological type. Conclusions CD4 4 V6 is not an ideal indicator to judge the prognosis of breast cancer. C erbB 2 can be used as an index to judge the prognosis of breast cancer. The significance of ER and PR determination is to guide the choice of clinical treatment options.