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[目的]回顾性分析不同年龄组IgA肾病患者的病理改变特点,以利于早期诊断和治疗。[方法]将我院795例(2000～2008年)经皮肾穿刺活检确诊为原发性IgA肾病的患者按不同年龄分为儿童组、青-中年组和老年组,逐项分析病例组织光镜和免疫荧光检查的相关资料。[结果]在795例病理资料中,儿童组患者病理学分级以Ⅰ～Ⅱ级为主,免疫荧光检查以单纯IgA+IgM+C3沉积多见;青-中年组患者病理学分级以Ⅰ～Ⅲ级为主,免疫荧光检查也是以单纯IgA+IgM+C3沉积多见;老年组病理学改变从Ⅰ～Ⅳ级均可见到,主要以Ⅲ～Ⅳ级为主,免疫荧光检查以IgA+C3、IgA+IgM+C3沉积较多。[结论]IgA肾病的病理改变有随着年龄增大,病理改变越明显肾脏损害越严重的趋势,早期进行经皮肾活检有利于明确诊断及尽早治疗。
[Objective] To retrospectively analyze the pathological changes of patients with IgA nephropathy in different age groups in order to facilitate early diagnosis and treatment. [Methods] The patients diagnosed as primary IgA nephropathy by percutaneous renal biopsy from 795 cases (2000 ~ 2008) in our hospital were divided into children group, middle-aged and middle-aged group according to different ages, Light microscopy and immunofluorescence related information. [Results] Among the 795 cases of pathological data, the pathological grade of children was mainly grade Ⅰ ~ Ⅱ, and the immunofluorescence was more common in simple IgA + IgM + C3 deposition. The pathological grade of young - middle age group was Ⅰ ~ Ⅲ grade, immunofluorescence is also more simple IgA + IgM + C3 deposition; pathological changes in the elderly group can be seen from Ⅰ ~ Ⅳ grade, mainly Ⅲ ~ Ⅳ grade, immunofluorescence with IgA + C3 , IgA + IgM + C3 deposition more. [Conclusion] The pathological changes of IgA nephropathy tend to be more serious with the increase of age and pathological changes. Early percutaneous renal biopsy is helpful for the definite diagnosis and treatment as soon as possible.