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土荆皮甲酸(Pseudolaric acid A),是从金钱松(Pseudolarix kamepferi)的根皮中分离得到的一个新型的二萜类化合物,将其混悬于1%羧甲基纤维素中,经口服给药,对大鼠、仑鼠及狗均可产生明显的抗早孕作用,其抗早孕的有效剂量各为7.5mg/kg,60mg/kg,0.5mg/kg qd×3d,土荆皮甲酸经皮下及阴道给药也能产生明显的抗早孕作用,其对大鼠口服的ED_(50),LD_(50)及95%可信限是14.5(11.7～17.7)mg/kg和219.8(193～250)mg/kg,得治疗指数10.2。狗的亚急性毒性试验表明,土荆皮甲酸对狗的中毒作用主要为呕吐、腹泻、便血等消化道的症状,显微镜下可见胃肠道粘膜及粘膜下组织广泛的出血点,其它器官未见到明显的病理变化。
Pseudolaric acid A, a new type of diterpenoid isolated from the root bark of Pseudolarix kamepferi, is suspended in 1% carboxymethylcellulose and is orally administered Drugs, rats, rats and dogs can have a clear anti-pregnancy effect of anti-early pregnancy effective doses of 7.5mg / kg, 60mg / kg, 0.5mg / kg qd × 3d, And vaginal administration can also produce significant anti-pregnancy effect, its oral administration of ED 50, LD 50 and 95% confidence limits 14.5 (11.7-17.7) mg / kg and 219.8 (193-250 ) mg / kg, the treatment index 10.2. The subacute toxicity test showed that the main poisoning effect of Cinobufagin on dogs was digestive symptoms such as vomiting, diarrhea and blood in the stool. Gastrointestinal mucosa and submucosal bleeding were seen under the microscope and no other organs were found To the obvious pathological changes.