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目的 为延长盐酸氯胺酮的作用时间 ,便于给药 ,制成盐酸氯胺酮控释片。方法 以HPMC(羟丙基甲基纤维素 )及Carbopol 934p(卡泊姆 )为辅料 ,制成胃内漂浮片并进行体外累积释放度测定。结果 体外释药基本达到零级释放过程 ,r=0 .940 4,体外释药量与释药时间具有良好的相关性。Peppas方程中n值为 0 .5 10 9,控释片中药物的释放机制是亲水凝胶层扩散和骨架溶蚀。结论 盐酸氯胺酮控释片达到了设计的要求 ,5min内体外释药约为标示量的 10 %左右 ,6h后释药约 90 %左右
The purpose is to extend the role of ketamine hydrochloride time, ease of administration, made of ketamine hydrochloride controlled release tablets. Methods HPMC (hydroxypropyl methylcellulose) and Carbopol 934p (Carphem) were used as excipients to make gastric floating tablets and to determine the cumulative release in vitro. Results in vitro release basically reached the zero-order release process, r = 0. 940 4, in vitro release and release time has a good correlation. In the Peppas equation, the value of n is 0. 5 10 9. The drug release mechanism in controlled release tablets is diffusion of hydrophilic gel layer and skeleton erosion. Conclusion Ketamine hydrochloride controlled release tablets meet the design requirements. In vitro release in about 5 minutes is about 10% of the labeled amount, about 90% after 6 hours