目的 :从GABA受体的角度进行探讨牛磺酸 (Tau)调节氨基酸释放的机理。方法 :将GABA受体的激动剂、拮抗剂加入悬浮有突触体的KRB液中 ,氨基酸测定采用Dans_Cl柱前衍生 ,高效液相测定。结果 :Tau对GABA释放的抑制作用能有效被GABAB受体的拮抗剂所拮抗 ,而它们对GluAsp的释放均无影响。结论 :Tau抑制去极化引发GABA的释放是通过激发突触体前膜GABAB 受体而起作用的 ,同时还作用于Asp、Glu神经末梢的突触体前膜 ,从而抑制去极化引发的Asp、Glu的释放 Objective: To investigate the mechanism of taurine (Tau) regulating amino acid release from the perspective of GABA receptor. Methods: GABA receptor agonists and antagonists were added to the synaptosomal KRB suspension. The amino acids were determined by Dans_Cl pre-column derivatization and HPLC. RESULTS: The inhibitory effect of Tau on GABA release was effectively antagonized by GABAB receptor antagonists, which did not affect GluAsp release. CONCLUSIONS: Tau-induced depolarization-initiated GABA release acts by activating the GABAB receptor on the presynaptic membrane of the synaptosome and also acts on the presynaptic membrane of the presynaptic Asp and Glu nerve terminals to inhibit depolarization-induced Asp, Glu release