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目的：综合防治造血干细胞移植（ＨＳＣＴ）早期的霉菌感染、方法：对３６例造血干细胞移植患者采用层流室隔离、无菌护理、肠道净化、Ｇ－ＣＳＦ的应用、口服氟康唑等综合防治感染措施。结果：仅１例可疑霉菌感染，经常规抗菌素治疗７２ ｈ无效，抗霉菌药物加大量，改为大扶康静满后２４ ｈ内感染控制。其中３例出现轻度肝功能损害，但程度轻，均在３周内恢复正常、结论：综合防治造血干细胞移植早期霉菌感染效果满意。
OBJECTIVE: To comprehensively prevent and treat early fungal infection of hematopoietic stem cell transplantation (HSCT). Methods: 36 patients undergoing hematopoietic stem cell transplantation were treated with laminar compartment isolation, sterile care, intestinal cleansing, G-CSF application, oral fluconazole, etc. Prevention of infections. RESULTS: Only one case of suspicious fungal infection was treated with conventional antibiotics for 72 h, and a large amount of antifungal drugs was added. The infection control was changed within 24 h after DFW. Three of them had mild liver function damage, but the severity was mild and all returned to normal within 3 weeks. Conclusion: The effect of comprehensive prevention and treatment of fungal infection of hematopoietic stem cell transplantation was satisfactory.