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目的研究甲状腺转录因子-1(Thyroid transcription factor-1,TTF-1)在肺腺癌(lung adenocarcinoma)患者血清中的表达水平及临床意义。方法采用酶联免疫吸附法(ELISA)检测46例肺腺癌患者血清中TTF-1的浓度,以43例健康者作为对照,分析TTF-1的表达与肺腺癌患者临床病理特征及预后的关系。结果肺腺癌患者血清中TTF-1浓度[(1.00±0.34)ng/mL]明显高于健康者[(0.72±0.28)ng/mL],差异有统计学意义(P<0.05)。TTF-1表达水平与患者性别、年龄、吸烟史及淋巴转移、TNM分期等临床病理特征无关(P>0.05)。另外,Kaplan-Meier分析结果显示,TTF-1高表达组患者的生存时间明显低于低表达组,差异有统计学意义(P<0.05)。采用Cox比例风险回归模型进行多因素分析发现,TTF-1表达水平及肿瘤TNM分期是影响肺腺癌患者预后的独立危险因素。结论 TTF-1在肺癌的发生、发展中起一定作用,检测其血清含量对肺腺癌的诊断具有重要的临床意义,其在血清中的过高表达有可能作为肺腺癌患者不良预后的评估指标。
Objective To investigate the expression and clinical significance of Thyroid transcription factor-1 (TTF-1) in the serum of patients with lung adenocarcinoma. Methods The serum concentrations of TTF-1 in 46 patients with lung adenocarcinoma were detected by enzyme-linked immunosorbent assay (ELISA). Forty-three healthy controls were used as controls to analyze the relationship between the expression of TTF-1 and the clinicopathological characteristics and prognosis of lung adenocarcinoma relationship. Results The serum TTF-1 level in patients with lung adenocarcinoma was significantly higher than that in healthy controls [(1.00 ± 0.34) ng / mL vs (0.72 ± 0.28) ng / mL, P <0.05). The expression level of TTF-1 was not related to clinicopathological features such as sex, age, smoking history, lymphatic metastasis and TNM stage (P> 0.05). In addition, Kaplan-Meier analysis showed that the survival time of TTF-1 high expression group was significantly lower than that of low expression group (P <0.05). Multivariate analysis using Cox proportional hazards regression model found that TTF-1 expression and tumor TNM stage were independent prognostic factors of lung adenocarcinoma. Conclusion TTF-1 plays a role in the occurrence and development of lung cancer. Detection of its serum content has important clinical significance in the diagnosis of lung adenocarcinoma. The overexpression of TTF-1 in serum may be used as an assessment of poor prognosis in patients with lung adenocarcinoma index.