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目的 :评价复方抗瘤冲剂配合静脉化疗对老年胃肠道肿瘤患者免疫功能的影响。方法 :老年胃肠道肿瘤患者 4 3例随机分为两组 :对照组 2 2例 ,用甲酰四氢叶酸钙、5 氟尿嘧啶、丝裂霉素方案行静脉化疗 ;治疗组 2 1例 ,在静脉化疗同时 ,服用复方抗瘤冲剂。化疗前及化疗 2个疗程结束后 (6周 )分别检测外周血常规、免疫球蛋白、T淋巴细胞亚群 ,进行统计学分析。结果 :化疗结束时治疗组患者外周血中白细胞、血小板计数、血红蛋白较化疗前无明显下降 ;与对照组比较 ,治疗组免疫球蛋白IgG、IgM及T淋巴细胞亚群CD+ 4 、CD+ 4 /CD+ 8值均有提高 ,两组差异均有统计学意义。结论 :复方抗瘤冲剂可有效提高老年胃肠道肿瘤患者机体免疫功能 ,使患者平稳经受化疗。
Objective: To evaluate the effect of Fufang Kangliu granules combined with intravenous chemotherapy on immune function in elderly patients with gastrointestinal cancer. Methods: 43 elderly patients with gastrointestinal cancer were randomly divided into two groups: control group, 22 patients received leucovorin, 5 fluorouracil and mitomycin chemotherapy; 21 patients in the treatment group were treated with Intravenous chemotherapy at the same time, taking compound anti-tumor granules. Peripheral blood routine, immunoglobulin and T lymphocyte subsets were detected before chemotherapy and after 2 courses of chemotherapy (6 weeks), respectively, for statistical analysis. Results: Compared with the control group, the levels of leucocyte, platelet count and hemoglobin in the peripheral blood of patients in the treatment group after chemotherapy were not significantly decreased. Compared with the control group, the immunoglobulin IgG, IgM and T lymphocyte subsets CD + 4 and CD + 4 / CD + 8 values were increased, the difference between the two groups were statistically significant. Conclusion: Fufang Kangao granules can effectively improve the immune function of the elderly patients with gastrointestinal cancer, so that the patient undergoes stable chemotherapy.