支气管对非特异性刺激反应性增高是过敏性和非过敏性哮喘的一个主要特征。这种现象的病因学还不清楚,目前人们倾向于炎症学说。在过敏性炎症过程中,发现很多细胞和介质。它们都可引起气道上皮损害,因而参与支气管高反应性的产生。嗜酸细胞已成为最近人们研究的重点。能抑制嗜酸细胞数量和活性的药物似乎对治疗过敏性疾病很有效。我们研究了免疫治疗对支气管高反应性的作用和某些反映嗜酸细胞活性的生化指标的波动情况。在季节性过敏性疾病模型中,我们追随了嗜酸细胞阳离子蛋白(ECP)和嗜 Bronchial response to nonspecific stimuli is a major feature of allergic and non-allergic asthma. Etiology of this phenomenon is not clear, at present people tend to inflammation theory. During allergic inflammation, many cells and media are found. They can cause damage to airway epithelium, and thus involved in the production of bronchial hyperresponsiveness. Eosinophilus has become the focus of recent research. Drugs that inhibit eosinophil numbers and activity appear to be effective in treating allergic diseases. We examined the effects of immunotherapy on bronchial hyperreactivity and the variability of certain biochemical markers that reflect eosinophil activity. In a seasonal allergic disease model, we followed eosinophil cationic protein (ECP) and addicted