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目的研究直肠癌组织中SLP-2基因的表达情况。方法应用免疫组化法及RT-PCR法检测40对直肠癌及其癌旁正常直肠组织中SLP-2蛋白及mRNA的表达情况,分析直肠癌病例临床病理特征与SLP-2蛋白表达的关系。结果免疫组化及RT-PCR结果显示SLP-2在直肠癌组织中的表达高于正常配对直肠组织(均P<0.05),且SLP-2蛋白的表达与直肠癌TNM分期及有无淋巴结转移相关(均P<0.05)。结论 SLP-2基因在直肠癌组织中表达升高,可能参与直肠癌的发生发展和转移。
Objective To study the expression of SLP-2 gene in rectal cancer. Methods The expressions of SLP-2 protein and mRNA in 40 rectal cancer tissues and normal colorectal tissues were detected by immunohistochemistry and RT-PCR. The relationship between SLP-2 protein and clinical pathological features was analyzed. Results The results of immunohistochemistry and RT-PCR showed that the expression of SLP-2 in rectal cancer tissues was higher than that in normal matched rectal tissues (all P <0.05), and the expression of SLP-2 protein was correlated with TNM stage and lymph node metastasis Related (all P <0.05). Conclusion The expression of SLP-2 gene in rectal cancer tissue may be involved in the development and metastasis of rectal cancer.