阿片受体激动药物主要指作用于μ受体的激动剂,由于具有强大的镇痛作用,在临床麻醉与镇痛中应用广泛。1979年,Wang等[1]首次在人体鞘内注射吗啡用于急、慢性疼痛治疗,由此开创了阿片受体激动药物鞘内应用的新纪元。在此后的30余年,众多学者一直致力于阿片受体激动药物鞘内应用的研究,以获得安全、有效、持久的节段性镇痛作用,减少其全身应用的副作用。本文将就阿片受体激动药物鞘内应用的研 Opioid agonists mainly refer to agonists acting on the mu receptor, which are widely used in clinical anesthesia and analgesia because of their strong analgesic effect. In 1979, Wang et al [1] first injected intrathecal morphine into the human body for the treatment of acute and chronic pain, thus creating a new era of intrathecal opioid agonist use. In the following 30 years, many scholars have been committed to the study of intrathecal opioid agonist drugs in order to obtain a safe, effective and lasting segmental analgesic effect and reduce the side effects of its systemic application. This article will opioid receptor agonist intrathecal application