以邻氨基苯酚(硫酚)和尿素为起始原料,经一系列反应,合成出了30个新型含噁二唑环的苯并噁/噻唑啉酮衍生物(6).利用IR、1H NMR和元素分析对新化合物4和6的结构进行了表征.对所合成的目标化合物进行了抗癌、抗炎和免疫调节活性的筛选,实验结果表明,部分目标化合物具有弱的抗癌和免疫调节活性,对TNF-α和Cdc25B磷酸酯酶均无抑制活性. Thirty new benzoxetane / thiazolone derivatives containing oxadiazole ring were synthesized by a series of reactions using o-aminophenol (thiophenol) and urea as starting materials. (6) IR, 1H NMR And elemental analysis were used to characterize the structures of new compounds 4 and 6. The target compounds were screened for their anti-cancer, anti-inflammatory and immunomodulatory activity. The experimental results show that some of the target compounds have weak anticancer and immunomodulatory Activity, no inhibitory activity on TNF-alpha and Cdc25B phosphatase.