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为了指导治疗,本文就劳力型心绞痛患者的抗血管性效应与异搏停及其代谢产物的血清浓度间的关系作了研究。材料与方法:选择对象为9例稳定性劳力型心绞痛的男性患者(平均年龄50±2岁),按(?)分级法心功能为Ⅱ～Ⅲ级。其中4例有心肌梗塞史,6例冠脉造影显示冠脉1～3支狭窄性损害。治疗前心绞痛发作频率>7次/周。双倍二阶梯负荷试验均显典型心绞痛发作伴ST段压低>1mm。为评价药物的抗血管性效应(△%),分别于投药后1、2、3和6h再作心电图负荷试验,并对投药前
In order to guide the treatment, this article studies the relationship between the anti-vascular effects of patients with angina pectoris and the serum concentrations of verapamil and its metabolites. MATERIALS AND METHODS: Nine male patients with stable angina pectoris (mean age 50 ± 2 years) were enrolled in this study. Cardiac function was classified as grade Ⅱ ~ Ⅲ according to the classification method. Among them, 4 patients had a history of myocardial infarction and 6 coronary angiography showed 1 ~ 3 coronary artery stenosis. Pre-treatment angina frequency> 7 beats / week. Double two-step load test showed typical angina attack with ST-segment depression> 1mm. To evaluate the anti-angiogenic effect of the drug (Δ%), an electrocardiogram load test was performed at 1, 2, 3 and 6 h after dosing,