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目的:比较LCM、LCA两种治疗方案用于根除幽门螺杆菌感染的疗效,探讨细菌耐药对疗效的影响。方法:选择HP感染患者350例,随机分成A组(兰索拉唑30mg,Bid;克拉霉素500mg,Bid;甲硝唑400mg,Bid);B组(兰索拉唑30mg,Bid;克拉霉素500mg,Bid;阿莫西林1 000mg,Bid)。结果:B组的HP根除率显著高于A组。结论:建议以PPI联合克拉霉素、阿莫西林为根除HP的一线治疗方案。
OBJECTIVE: To compare the curative effects of LCM and LCA on eradication of Helicobacter pylori infection and to explore the effect of bacterial resistance on the curative effect. Methods: A total of 350 patients with HP infection were selected and randomly divided into group A (lansoprazole 30mg, Bid; clarithromycin 500mg, Bid; metronidazole 400mg, Bid); group B (lansoprazole 30mg, Bid; Prime 500mg, Bid; amoxicillin 1000mg, Bid). Results: HP eradication rate in group B was significantly higher than that in group A. Conclusion: Proposed PPI combined with clarithromycin, amoxicillin for the eradication of HP first-line treatment.