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发生胸痛24小时内住院,确诊为急性心肌梗死的38例男性患者(年龄35～70岁),住院时随机分为安定组和对照组。凡曾服影响判断的药物(安定及其有关成份、皮质激素类、安他乐和甲基多巴)和有心源性休克、肺水肿以及有影响安定代谢的合并症(肾功能衰竭、肝硬化)患者均除外。安定组住院时即静注安定10毫克,1小时后口服15毫克,其后每8小时1次,连服3日。按预定时间测定皮质素、游离脂酸,门冬转氨酶(AST)和安定及其代谢物的血浓度。连续3天收集24小时尿量,测定肾上腺素、去甲肾上腺素、多巴胺浓度。患者住冠心病室,用示波器监测心律失常,观察患者的精神状态及安定的毒性。与对照组相比结果连续应用安定者比对照组有明显的优点,可减少不安和焦虑。仅在用药的初24小时,
Thirty-eight male patients (aged 35- 70 years) hospitalized for chest pain within 24 hours and diagnosed as having acute myocardial infarction were randomly divided into diazepam and control group during hospitalization. Anyone who has taken medications that affect judgment (diazepam and its related substances, corticosteroids, andalbumine, and methyldopa) and those with cardiogenic shock, pulmonary edema, and comorbidities that affect diazepam (renal failure, cirrhosis Patients excluded. Diazepam stable intravenous group stability 10 mg, 1 hour after oral administration of 15 mg, and every 8 hours thereafter, even for 3 days. Cortisol, free fatty acids, aspartate aminotransferase (AST), and diazepam and their metabolites were measured for blood concentrations over a predetermined period of time. Collect urine for 24 hours for 3 consecutive days, and determine epinephrine, norepinephrine and dopamine concentration. Patients with coronary heart disease room, with an oscilloscope to monitor arrhythmia, observe the patient’s mental state and stability of the toxicity. Compared with the control group, the results of continuous application of stability than the control group has obvious advantages, can reduce anxiety and anxiety. Only in the first 24 hours of medication,