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目的:探究自拟参花洗剂联合智能肛周熏洗仪对肛瘘术后创面愈合及新生血管的影响。方法:选取2018年1月至2019年6月于荆门市第二人民医院接受肛瘘瘘管切除术治疗的肛瘘患者120例，按照随机数字表法将其分为A组（n n=40）、B组（n n=40）及C组（n n=40）。A组术后予以自拟参花洗剂联合智能肛周熏洗仪进行熏洗治疗，B组术后予以自拟参花洗剂联合坐浴熏洗法进行熏洗治疗，C组予以高锰酸钾坐浴熏洗法治疗。记录三组临床疗效及随访期间不良反应发生情况，并分别于治疗前后评估三组创面愈合及新生血管情况。n 结果:治疗后，A组新生毛细血管数、成纤维细胞数及转化生长因子-β1（TGF-β1）、金属蛋白酶-1组织抑制剂（TIMP-1）、血管内皮生长因子-A（VEGF-A）水平均高于B组及C组[（13.65±2.25）vs（11.23±2.01）vs（9.34±1.62）,（52.40±5.53）vs（45.40±4.93）vs（37.89±4.49）,（1803.68±128.25）vs（1694.48±119.95）vs（1579.24±111.54）,（86.91±8.25）vs（78.88±7.53）vs（65.07±6.22）,（183.76±16.40）vs（156.29±14.31）vs（109.09±10.44）]，B组高于C组（n P<0.01）；A组疼痛评分、水肿评分、渗液评分及单核细胞趋化蛋白-1（MCP-1）水平均明显低于B组及C组[（0.78±0.34）vs（1.27±0.39）vs（1.85±0.51）,（0.19±0.07）vs（0.33±0.09）vs（0.50±0.11）,（0.18±0.07）vs（0.23±0.09）vs（0.29±0.12）,（85.49±9.27）vs（97.26±10.60）vs（129.69±12.42）]，B组低于C组；此外，A组总有效率较B及C组更高，组间差异有统计学意义（n χ2=4.11,14.05, n P<0.05），B组总有效率较C组更高，组间差异有统计学意义（n χ2=3.80, n P0.05）。n 结论:自拟参花洗剂联合智能肛周熏洗仪用于肛瘘患者能显著减少术后水肿及疼痛，促进新生血管形成与上皮组织增生，继而加快创面早期愈合进程。“,”Objective:To investigate the effect of self-made Shenhua lotion combined with intelligent perianal fumigation and washing instrument on wound healing and neovascularization after anal fistula operation.Methods:120 patients with anal fistula who received anal fistula fistula resection at the Second People’s Hospital of Jingmen from Jan. 2018 to Jun. 2019 were selected and divided into group A (n n=40) , group B (n n=40) and Group C (n n=40) according to the random number table method. Group A were given a self-made ginseng flower lotion combined with an intelligent perianal fumigation instrument for postoperative fumigation treatment, group B were given a self-made ginseng flower lotion combined with a sitting bath fumigation for fumigation treatment, and group C were given high manganese treatment of potassium acid sitting bath fumigation. The clinical efficacy of the three groups and the occurrence of adverse reactions during follow-up were recorded, and the wound healing and neovascularization of the three groups were evaluated before and after treatment.n Results:After treatment, the number of new capillaries, fibroblasts and TGF-β1, TIMP-1 and VEGF-A1 in group A were higher than those in group B and group C[ (13.65±2.25) vs (11.23±2.01) vs (9.34±1.62) , (52.40±5.53) vs (45.40±4.93) vs (37.89±4.49) , (1803.68±128.25) vs (1694.48±119.95) vs (1579.24±111.54) , (86.91±8.25) vs (78.88±7.53) vs (65.07±6.22) , (183.76±16.40) vs (156.29±14.31) vs (109.09±10.44) ], and group B were higher than those of group C (n P<0.01) . The pain score, edema score, exudate score and MCP-1 level in group A were significantly lower than those in group B and group C[ (0.78±0.34) vs (1.27±0.39) vs (1.85±0.51) , (0.19±0.07) vs (0.33±0.09) vs (0.50±0.11) , (0.18±0.07) vs (0.23±0.09) vs (0.29±0.12) , (85.49±9.27) vs (97.26±10.60) vs (129.69±12.42) ], and they were lower in group B than in group C (n P<0.01) . In addition, the total effective rate of group A was higher than that of group B and group C, and the difference between groups was significant (n χ2=4.11,14.05, n P<0.05) . The total effective rate of group B was higher than that of group C, and the difference between the groups was significant (n χ2=3.80, n P0.05) .n Conclusion:The self-made Shenhua lotion can significantly reduce postoperative edema and pain, promote the formation of new blood vessels and epithelial tissue proliferation, and then accelerate the early healing process of wounds.