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目的：研究病理明确诊断的小细胞肺癌采用自体外周血干细胞移植支持下的高剂量化疗的疗效。方法：６例患者选自常规化疗达到ＣＲ、ＰＲ或手术切除原发灶的小细胞肺癌对其采用自体外周血干细胞移植支持下的高剂量环磷酰胺ＣＴＸ、足叶乙甙ＶＰ－１６、卡铂ＣＢＰ的化疗ＣＴＸ ６ ０００ｍｇ／ｍ２ＶＰ－１６ １ ２００ｍｇ／ｍ２ＣＢＰ １ ２００ｍｇ／ｍ２其中５例进行了化疗后的局部放疗并进行了长期随访，中位随诊时间为２６．５１６～３３个月。结果：除１例小细胞肺癌死于高剂量化疗后２７个月余全部生存。最常见的毒副反应为恶心呕吐和粒细胞缺乏性发热未发现移植后的骨髓功能不全及其他严重并发症移植后３个月内的相关死亡率为零。结论：此方法对小细胞肺癌的治疗结果令人满意且较安全值得扩大病例数进一步研究。
OBJECTIVE: To study the efficacy of high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation in the pathologically confirmed small cell lung cancer. METHODS: Six patients were selected from routine chemotherapy to achieve CR, PR, or primary resection of small cell lung cancer. They were treated with autologous peripheral blood stem cell transplantation with high doses of cyclophosphamide CTX, and Acetobacter VP. -16. Carboplatin-CBP chemotherapy, CTX 6 000 mg/m2, VP-16 1, 200 mg/m2, CBP 1, 200 mg/m2, of which 5 cases received local radiotherapy after chemotherapy and long-term follow-up. The median follow-up time was 26.5 16 33 33 months. Results: Except one case of small cell lung cancer who died of high-dose chemotherapy 27 months later all survived. The most common toxicities were nausea and vomiting and agranulocytosis fever. No post-transplantation bone marrow insufficiency and other serious complications were found. The associated mortality within 3 months after transplantation was zero. Conclusion: This method is satisfactory for the treatment of small cell lung cancer, and it is safer and worthy of further study.