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目的分析2008-2014年常州市疑似预防接种异常反应(AEFI)的发生特征,评价AEFI监测系统运转情况和接种疫苗的安全性。方法通过中国免疫规划监测信息管理系统收集2008-2014年常州市报告的AEFI个案数据,相关指标采用描述性流行病学方法进行分析。结果 2008-2014年常州市报告的AEFI共9 800例,男女性别比例为1.32∶1,<1岁占36.10%,1岁占29.32%。报告数前3位的疫苗为无细胞百白破疫苗、B型流感嗜血杆菌(Hib)疫苗和白破疫苗。报告的AEFI中,一般反应占90.89%,异常反应占8.47%,其他<1%。临床诊断主要为发热/局部红肿/硬结和过敏性皮疹。结论常州市疑似预防接种异常反应监测敏感性不断提高,AEFI监测系统运转正常,疫苗的安全性较好。
Objective To analyze the characteristics of suspected immunization anomalies (AEFI) in Changzhou from 2008 to 2014 and evaluate the operation of AEFI monitoring system and the safety of vaccination. Methods The data of AEFI cases reported in Changzhou from 2008 to 2014 were collected through the China Immune Program Monitoring Information Management System. Relevant indexes were analyzed by descriptive epidemiological method. Results A total of 9 800 AEFI cases were reported in Changzhou City during 2008-2014. The male-female sex ratio was 1.32:1, accounting for 36.10% for <1 year old and 29.32% for 1-year-old. The top 3 vaccines reported were acellular diphtheriae vaccine, Hib vaccine and diphtheria vaccine. The reported AEFI, the general reaction accounted for 90.89%, abnormal reaction accounted for 8.47%, other <1%. Clinical diagnosis is mainly fever / local redness / induration and allergic skin rash. Conclusion The sensitivity of suspected immunization surveillance in Changzhou is continuously increasing. The AEFI monitoring system is in normal operation and the vaccine is safe.