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对我国49个县的心血管疾病(CVD,包括冠心病、高血压心脏病和脑卒中)死亡率和4900例35～64岁成年男女的膳食进行了调查,并测定了血浆脂质[总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和甘油三酸酯(TG)]的含量,结果指出:1.和西方国家人群比较,我国农民血浆TC、TG、HDL-C和依此计算而得的LDL-C水平较低,而HDL-C/TC比值较高,CVD死亡率也较西方国家的为低。2.在TC、LDL-C与CVD死亡率之间无相关,但在红细胞油酸水平与CVD死亡率间有显著负相关。3.红细胞油酸水平与血浆TC含量间无相关,而与红细胞花生四烯酸水平呈显著负相关。指出油酸对CVD死亡率的影响有可能是通过另一条途径,即减低血小板的聚集作用。4.我国的CVD死亡率呈现明显的地区性分布,即南方低于北方。其分布与红细胞油酸含量,及大米摄取量的地区性分布呈明显的负关系。5.为解释CVD死亡率与红细胞油酸的负关系,本文提出了油酸可能置换了血小板膜磷脂中多不饱和脂肪酸的设想,但对大米保护CVD的作用则尚需有更多的调查和研究数据才能确证之。
The mortality of cardiovascular diseases (CVD, including coronary heart disease, hypertensive heart disease and stroke) in 49 counties of China and the diet of 4900 adult men and women aged 35-64 years were investigated and the plasma lipids [total cholesterol (TC), HDL-C and triglyceride (TG), the results showed that: 1. Compared with Western countries, the levels of plasma TC, TG, HDL-C Calculated LDL-C levels lower, while the high HDL-C / TC ratio, CVD mortality is also lower than in Western countries. There was no correlation between TC, LDL-C and CVD mortality, but there was a significant negative correlation between erythrocyte oleic acid level and CVD mortality. There was no correlation between erythrocyte oleic acid level and plasma TC level, but negatively correlated with erythrocyte arachidonic acid level.3. Pointed out that the impact of oleic acid on CVD mortality may be through another approach, that is, to reduce platelet aggregation. 4. China’s CVD mortality showed a clear regional distribution, that is, the south is lower than the north. Its distribution and erythrocyte oleic acid content, and rice intake showed a significant negative regional distribution. 5. To explain the negative relationship between CVD mortality and erythrocyte oleic acid, this paper proposes the idea that oleic acid may displace PUFA in platelet membrane phospholipids. However, the role of rice in CVD protection needs more investigation and Research data can be confirmed.