论文部分内容阅读
目的探讨孟鲁司特钠治疗小儿过敏性咳嗽的临床疗效及其对患儿肺功能的影响。方法选取苏州市立医院2015年12月—2016年12月收治的小儿过敏性咳嗽患儿140例,根据治疗方案的不同分为对照组和观察组,各70例。对照组患儿采用盐酸丙卡特罗治疗,观察组患儿采用孟鲁司特钠治疗,两组患儿均持续用药14 d。比较两组患儿的临床疗效、咳嗽持续时间、复发率、治疗前后肺功能指标[第1秒用力呼气末容积(FEV1)、呼气高峰流量(PEFR)、用力肺活量(FVC)]及生活质量评分。结果观察组患儿治疗总有效率高于对照组(P<0.05)。观察组患儿咳嗽持续时间短于对照组,复发率低于对照组(P<0.05)。治疗前,两组患儿FEV1、PEFR、FVC比较,差异无统计学意义(P>0.05);治疗后,观察组患儿FEV1、PEFR、FVC高于对照组(P<0.05)。观察组患儿饮食、睡眠、精神状态及精力充沛评分高于对照组(P<0.05)。结论采用孟鲁司特钠治疗小儿过敏性咳嗽的临床疗效确切,可有效改善患儿的临床症状及肺功能,提高生活质量,且疾病复发率低。
Objective To investigate the clinical efficacy of montelukast sodium in the treatment of children with allergic cough and its effect on the lung function in children. Methods A total of 140 children with allergic cough in children admitted to Suzhou Municipal Hospital from December 2015 to December 2016 were selected and divided into control group and observation group with 70 cases in each group. Children in the control group were treated with procaterol hydrochloride. Patients in the observation group were treated with montelukast sodium, and both children were treated for 14 days. The clinical efficacy, duration of cough, relapse rate, pulmonary function parameters (FEV1, PEFR, FVC) and life expectancy before and after treatment were compared between the two groups Quality Score. Results The total effective rate of observation group was higher than that of control group (P <0.05). The duration of cough in observation group was shorter than that in control group, and the recurrence rate was lower than that in control group (P <0.05). Before treatment, FEV1, PEFR and FVC in two groups had no significant difference (P> 0.05). After treatment, FEV1, PEFR and FVC in observation group were higher than those in control group (P <0.05). Children in observation group had higher diet, sleep, mental status and energetic score than those in control group (P <0.05). Conclusion Montelukast sodium treatment of allergic cough in children with clinical efficacy of the exact, can effectively improve the clinical symptoms and lung function in children, improve quality of life, and the disease recurrence rate is low.