论文部分内容阅读
目的:比较硫酸妥布霉素iv gtt或气管滴入的药物动力学.方法:用EPIA法测定10例脑外伤病人ivgtt或气管滴入硫酸妥布霉素后的血药浓度.结果:2种给药方法均符合一房室模型的药物动力学特征,且给药后2h均能达到有效血浓度(2～12μg/ml),但血药浓度及主要药物动力学参数个体差异较大.结论:iv gtt给药用于脑外伤短期预防给药、气管滴入能有效地预防肺部感染.
Objective: To compare the pharmacokinetics of iv gtt or tracheal instillation.Methods: The plasma concentration of iv gtt or tracheal instillation of tobramycin in 10 traumatic brain injury patients was measured by EPIA.Results: The pharmacokinetics characteristics of one-compartment model were all consistent with the pharmacokinetic characteristics of one-compartment model, and the effective blood concentration (2 ~ 12μg / ml) could be reached at 2h after administration, but there were significant differences between the plasma concentration and the main pharmacokinetic parameters. : iv gtt administration for short-term prophylaxis of traumatic brain injury, tracheal instillation can effectively prevent lung infections.