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噻乙胺唑头孢菌素(Cefotiam,简称CTM,商品名Pansporin,日本武田药品工业株式会社产品),按Dunn’s分类属第二代头孢菌素,本品对革兰氏阴性细菌细胞外膜有良好的通透性,对β-内酰胺酶比较稳定,其作用机制为抑制细菌细胞壁的合成。 1984年我们应用CTM处理感染性疾病24例:儿科6例,内科12例,外科6例,另有术前后预防用药6例,共30例。CTM剂量,成人2～4g/d,分2～3次iv gtt,小儿100～200mg/d,分2～3次,iv或iv gtt,现将结果报道如下。
Cefotiam (Cefotiam, referred to as CTM, trade name Pansporin, Japan Takeda Pharmaceutical Industry Co., Ltd.), according Dunn’s classification is a second-generation cephalosporin, the product of gram-negative bacterial cell membrane is good Permeability, β-lactamase relatively stable, its mechanism of action for the inhibition of bacterial cell wall synthesis. In 1984, we applied CTM to treat 24 cases of infectious diseases: 6 cases of pediatrics, 12 cases of internal medicine and 6 cases of surgery, and 6 cases of preoperative and postoperative prophylaxis, 30 cases in total. CTM dose, adult 2 ~ 4g / d, 2 to 3 times iv gtt, children 100 ~ 200mg / d, 2 to 3 times, iv or iv gtt, the results reported below.