论文部分内容阅读
目的:观察丹红注射液联合脑心通胶囊对冠状动脉介入术后再狭窄的预防,研究其作用机制。方法:将经冠状动脉造影明确诊断为冠心病患者,术中成功行PCI治疗的病例64例随机分为两组,两组PCI术前、后常规口服阿司匹林、氯毗格雷、ACEI。β受体阻滞剂、他汀类及硝酸酯类药物。治疗组在PCI术前3～5天开始给予5%葡萄糖(或0.9%氯化钠)注射液250mL加人丹红注射液30mL静滴,1次/d;同时给予脑心通胶囊3粒口服,3次/d,疗程半年。PCI术前、后观察患者有无心绞痛,术后6个月复查心电图活动平板运动试验。阳性者行冠脉造影检查。于入院时及PCI术后2天、1周测定hs-CRP。血浆内皮素及血清一氧化氮于PCI术后4h和术后6个月各检测1次。比较两组之间PCI术后的心绞痛、临床再狭窄和造影再狭窄发生人数的差异。结果:治疗组疗效优于对照组。结论:常规治疗基础上应用丹红注射液联合脑心通胶囊可进一步有效预防冠脉介入术后再狭窄的放生。
Objective: To observe the Danhong injection combined with Naoxintong capsule on the prevention of restenosis after coronary intervention and study its mechanism. Methods: Sixty-four patients with coronary artery disease who underwent coronary angiography were successfully diagnosed. The patients undergoing PCI were randomly divided into two groups. The two groups received routine oral aspirin, clopidogrel and ACEI before and after PCI. β blockers, statins and nitrates. The patients in treatment group were given 30% intravenous drip of Danhong injection 30mL once a day for 5 ~ 5% dextrose (or 0.9% sodium chloride) injection 3 ~ 5 days before PCI. At the same time, 3 capsules of Naoxintong capsule , 3 times / d, course of six months. PCI before and after observation of patients with or without angina, 6 months after the review ECG treadmill exercise test. Positive line coronary angiography. Hs-CRP was measured at admission and 2 days after PCI and 1 week. Plasma endothelin and serum nitric oxide in the 4h after PCI and 6 months after the test every time. The difference between angina pectoris, clinical restenosis and contrast-induced restenosis after PCI was compared between the two groups. Results: The treatment group than the control group. Conclusion: Danhong injection combined with Naoxintong capsule can further prevent the restenosis after coronary intervention.