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目的:探讨单光子发射计算机化断层显像(SPECT)联合血清肿瘤标志物癌胚抗原(CEA)、细胞角蛋白片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)检测在肺部占位性病变性质判断中的应用价值。方法:选择本院收治的158例胸部CT检查证实为肺部占位病变并予以手术的患者为观察对象,全部观察对象术前均接受SPECT显像、NSE、CYFRA21-1以及CEA检查,结合术后病理结果做回顾性分析。结果:病理诊断结果显示,158例患者中良性病变40例,恶性病变118例。以病理诊断结果为依据展开分析,SPECT显像检查的敏感度为83.1%,特异度为80.1%,准确度为82.3%;肿瘤标志物的敏感度为78.8%,特异度为77.5%,准确度为78.5%;SPECT显像联合肿瘤标志物检查的敏感度为92.4%,特异度为90.0%,准确度为91.8%。可知联合检查组的敏感度、特异度、准确度最高。结论:SPECT显像联合血清CEA、CYFRA21-1、NSE检测是一种较为准确可靠的肺部占位性病变性质判断方法。
Objective: To investigate the diagnostic value of single photon emission computed tomography (SPECT) combined with serum tumor markers carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA21-1) and neuron specific enolase (NSE) The value of occupying lesions in judging the nature. Methods: One hundred and eighty cases of thoracic CT examination in our hospital were selected as the observation objects for the patients who had lung space occupying lesion. All the patients were examined by SPECT, NSE, CYFRA21-1 and CEA before operation, Post-pathological findings were retrospectively analyzed. Results: The pathological findings showed that in 158 patients benign lesions in 40 cases, 118 cases of malignant lesions. According to the results of pathological diagnosis, the sensitivity of SPECT imaging examination was 83.1%, the specificity was 80.1% and the accuracy was 82.3%. The sensitivity of tumor markers was 78.8% and the specificity was 77.5%. The accuracy Was 78.5%. The sensitivity of SPECT combined with tumor markers was 92.4%, the specificity was 90.0% and the accuracy was 91.8%. It can be seen that the joint inspection team has the highest sensitivity, specificity and accuracy. Conclusion: SPECT imaging combined with serum CEA, CYFRA21-1 and NSE detection is a more accurate and reliable method for judging the nature of lung space-occupying lesions.