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一个新抗生素能否用于治疗化脓性关节炎,主要看它透入化脓性关节炎的关节腔的能力。然而化脓性关节炎的病例较少,而风湿性关节炎急性发作的病人,其关节腔滑液的性质与化脓性关节炎滑液的性质相似。因此,作者用15例风湿性关节炎急性发作的志愿者进行实验性观察,患者分5组,每组3例,以观察头孢三嗪(Ceftriaxone,CTA)的药物动力学及药物透入滑液的能力。患者一次静脉注射1gCTA,药后1、2、3、4和8小时取血样及滑液样品,8～24小时
Whether a new antibiotic can be used to treat septic arthritis depends primarily on its ability to penetrate the articular cavity of the suppurative arthritis. However, fewer cases of suppurative arthritis, rheumatoid arthritis and acute attack in patients with synovial synovial synovial fluid of the nature and the nature of the nature of suppurative arthritis synovial fluid. Therefore, the authors used 15 cases of acute exacerbation of rheumatoid arthritis volunteers for experimental observation, the patients were divided into 5 groups, 3 cases in each group to observe the ceftriaxone (Ceftriaxone, CTA) pharmacokinetics and drug penetration synovial fluid Ability. Patients once intravenous injection of 1gCTA, 1,2,3,4 and 8 hours after taking blood samples and synovial fluid, 8 to 24 hours