药物不只是与它的靶标,而是可以与体内的许多蛋白相互作用。有一些是我们不想要的分子相互作用,就成为副作用。其程度有轻有重。若能事先预见它们,医生就可以设法避免或对抗它们。但要想预告一种药物在体内可能出现什么副作用,常不易做到。加州大学Brian K Shoichat和Novartis生物医学研究所的L Urban研发了一种预告药物可能出现的副作用的新方法。他们用一种名为“Similarity ensemble approach”的电脑计算方法。根据药物的化学结构,计算出它的何种分子可能与病人身体的分 A drug is not just its target, but it interacts with many proteins in the body. Some are molecular interactions that we do not want to be side effects. The degree of light and heavy. If you anticipate them in advance, the doctor can try to avoid or fight them. However, it is often not easy to predict what side effects a drug may have in the body. Brian K Shoichat of the University of California and L Urban of the Novartis Institute for Biomedical Research developed a new way to predict possible side effects of drugs. They used a computerized method called “Similarity ensemble approach ”. According to the chemical structure of the drug, it is calculated which molecules of the drug may interact with the patient’s body