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Many postmenopausal women with low-density lipoprotein-cholesterol (LDL-C) ＜130 mg/dL from Chaoshan region suffer from coronary artery diseases,especially severe coronary artery lesions.However,few studies specifically focused on the cardiovascular risks of this subgroup of postmenopausal women.Methods A total of 270 postmenopausal women with LDL-C＜130 mg/dL from Chaoshan region were enrolled in this cohort study.Patients with angiographically proven coronary artery diseases (CAD) served as CAD group (n=174),while the ones with angiographically proven normal coronary arteries served as Control group (n=96).Results The age of CAD group (68.5±8.4 years) was older than that of Control group (60.0±6.9 years) (P＜0.001).The prevalence rates of hypertension,diabetes mellitus (DM) and hyperuricemia in CAD group were significantly higher than those of Control group (P＜0.05 for both comparisons).The serum level of uric acid (UA) in CAD group was significantly higher than that in Control group (P＜0.001).Age,DM and UA were independent cardiovascular predictors of postmenopausal women with LDL-C＜130 mg/dL from Chaoshan Region [ORAGE:1.140 (95％CI:1.095-1.188),ORDM:2.740 (95％CI:1.368-5.486),ORUA:1.003 (95％CI:1.001-1.006),PAGE＜00.001,PDM=0.004,PUA=0.019].Conclusions Postmenopausal women with LDL-C＜130 mg/dL complicating CAD are elder with higher prevalence rates of hyperuricemia and DM.Age,DM and UA are considered as independent cardiovascular risk factors in the postmenopausal women with LDL-C ＜ 130 mg/dL from Chaoshan Region of China.