皮脂角化症(SK)是一种很常见的良性增生性皮肤损害。可见于约20％的中老年 人。除瘙痒性发疹性SK常与内脏恶性肿瘤有关(Leser-trelat征)外,一般常仅由于美容上的原因而引起人们的注意,也很少进行病理学的检查。但在以往的文献中,有散在报告SK转变为恶性肿瘤。本文回顾性研究临床诊断的SK损害,在组织病理学上的恶变发生率,并对其年龄、部位的分布进行分析。 Sebometriosis (SK) is a very common benign proliferative skin lesion. It is found in about 20% of middle-aged and old people. In addition to pruritic eruptive SK often associated with visceral malignancy (Leser-trelat sign), it is often only due to cosmetic reasons that cause attention, and rarely pathological examination. However, in the previous literature, scattered reports have turned SK into malignant tumors. This article reviews retrospectively the clinical diagnosis of SK lesions, the incidence of histopathological malignancy, and the distribution of their age and location.