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目的 比较盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的药动学差异.方法 正常大鼠与糖尿病模型大鼠,分别灌胃给予盐酸二甲双胍后,于不同时间点采集血样,用HPLC测定血药浓度并绘制药.时曲线,用DASl.0统计软件计算药动学参数.结果 盐酸二甲双胍在正常大鼠与糖尿病大鼠体内的主要药动学参数分别为:Cmax=9.41μg·mL-1、t1/2=161.8min、C1/F=0.079 L·min-1·kg-1;Cmax=20.09 μg·mL-1、t1/2=1 718.93 min、C1/F=0.012 L·min-1·kg-1.结论 盐酸二甲双胍在正常大鼠与糖尿病模型大鼠体内的药动学参数有明显差异(P<0.05).“,”OBJECTIVE To compare the phannacokinetic differences of metformin hydrochloride between normal and diabetic rats.METHODS Metformin hydrochloride was orally administrated to the normal and diabetic rats.The blood samples were collected at different time.The concentration of metformin hydrochloride in plasma was determined by HPLC method.The software of DAS 1.0 was used to estimate the pharmacokinetic parameters.RESULTS The main pharmacokinetic pharmacokinetic parameters of metformin hydrochloride in normal and diabetic rats have significant differences (P<0.05).