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目的:探讨中药灯盏花素注射液对脑出血患者氧化应激的影响。方法:实验分成两组,以30例健康人为对照组,以25例早期脑出血患者为实验组,采用灯盏花素进行治疗,观察治疗前后两组血液中SOD、LDH的活性及MDA的含量。结果:与对照组相比,治疗前实验组SOD活性降低,而LDH的活性和MDA的含量升高。采用灯盏花素治疗后,实验组SOD显著升高,LDH的活性和MDA的含量降低;与对照组相比,无明显差异。结论:灯盏花素可通过抑制中性粒细胞产生呼吸爆发、脱颗粒,增强机体清除氧自由基的能力,并降低脂质过氧化损伤,可应用于治疗早期脑出血。
Objective: To investigate the effect of breviscapine injection on oxidative stress in patients with intracerebral hemorrhage. Methods: The experiment was divided into two groups. Thirty normal controls were used as control group. Twenty-five patients with early cerebral hemorrhage were used as experimental group. Breviscapine was used for the treatment. The activities of SOD and LDH and the contents of MDA were observed before and after treatment. Results: Compared with the control group, the activity of SOD and the content of MDA in the experimental group before treatment were decreased. After using breviscapine treatment, the experimental group SOD increased significantly, LDH activity and MDA content decreased; compared with the control group, no significant difference. Conclusion: Breviscapine can be used to treat early cerebral hemorrhage by inhibiting neutrophil respiratory burst, degranulation, enhancing the ability of the body to scavenge oxygen free radicals and reducing lipid peroxidation damage.