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研究全新放射增敏剂－磺酰胺基取代的咪唑化合物（化学名：１－取代－４－磺酰胺基咪唑，简称ＩＶｂ。）对荷Ｈ２２肝癌小鼠的放射增敏作用。实验结果表明：与空白对照组相比，照射前腹腔注射Ｉｖｂ０．５８～０．１４ｇ／ｋｇ后，肿瘤体积变小，肿瘤相对增长速度明显减小，肿瘤抑制率增加，肿瘤生长延迟天数也有一定程度增加，表现出ＩＶｂ对肿瘤生长的抑制作用，其中以照射前注射０．２９ｇ／ｋｇ剂量组最明显（肿瘤抑制率为４８％）。而单纯照射组、单纯用药（高、中、低剂量）组和空白对照组相比，则没有明显的抑制肿瘤作用。与单纯照射组相比，照射加用药０．２９ｇ／ｋｇ，肿瘤相对增长速度明显减小，肿瘤抑制率增加，肿瘤生长延迟天数也有一定程度增加。由此可见，ＩＶｂ对Ｈ２２肝癌具有放射增敏作用。
To study the radiosensitization effect of a new radiosensitizer-sulfonamido substituted imidazole compound (chemical name: 1-substituted-4-sulfonamidoimidazole, referred to as IVb.) On H22 hepatoma mice. The experimental results showed that compared with the blank control group, the intraperitoneal injection of Ivb 0.58 ~ 0.14g / kg before irradiation decreased the volume of the tumor, the relative growth rate of the tumor was significantly reduced, the tumor inhibition rate increased, and the number of days of tumor growth delay was also certain The degree of increase, showing the inhibitory effect of IVb on tumor growth, of which 0.29g / kg dose group before irradiation was the most obvious (tumor inhibition rate was 48%). Compared with the blank control group, there was no obvious inhibitory effect of the tumor in the simple irradiation group (high, middle and low dose) alone group. Compared with the pure irradiation group, irradiation plus drug 0.29g / kg, the relative growth rate of tumor was significantly reduced, the tumor inhibition rate increased, the number of days the tumor growth delay also increased to some extent. Thus, IVb on H22 hepatoma with radiosensitization.