用推～挽灌流技术，定位灌流大鼠下丘脑后部，同时ｉｖ给予去氧肾上腺素（１５μｇ·ｋｇ·ｍｉｎ－１）和静脉输血（３ｍｌ／１００ｇ，ｗｔ）引起血压升高时，下丘脑后部γ－氨基丁酸（ＧＡＢＡ）的释放率增加，而ｉｖ给予硝普钠、氯化四氯吲哚铵和控制性失血导致血压下降时，ＧＡＢＡ的释放率减少。进一步证明下丘脑ＧＡＢＡ能神经系统参与外周动脉血压的调节，且有降压作用。 The hypothalamus was located at the posterior part of the hypothalamus in the perfused rat by push-pull perfusion. At the same time, the hypothalamus was induced by iv injection of phenylephrine (15μg · kg · min-1) and intravenous transfusion (3ml / 100g, wt) The release of gamma-aminobutyric acid (GABA) was increased in the posterior part, whereas the release of GABA was reduced with iv administration of sodium nitroprusside, tetrachloroindolium chloride and controlled blood loss leading to a drop in blood pressure. Further evidence that hypothalamic GABAergic nervous system involved in the regulation of peripheral arterial pressure, and antihypertensive effect.