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目的探讨血清透明质酸（ｈｙａｌｕｒｏｎｉｃａｃｉｄ，ＨＡ）和甘氨胆酸（ｃｈｏｌｙｌｇｌｙｃｉｎｅ，ＣＧ）联合检测对肝硬化进展和预后判断以及对提高早期肝硬化诊断阳性率的临床意义。方法将１１３例肝炎后肝硬化患者按ｃｈｉｌｄ分级，分为Ａ、Ｂ、Ｃ三组，采用放免法测定肝硬化患者血清ＨＡ和ＣＧ，对计量资料进行方差检验，对计数资料进行卡方检验。结果血清ＨＡ值（ｎｇ／ｍｌ），ｃｈｉｌｄＡ级：２６２．１５±２３６．０２，Ｂ级：４９８．４２±１８５．７４，Ｃ级：６０９．８９±１４１．８７；血清ＣＧ值（ｎｇ／ｍｌ），ｃｈｉｌｄＡ级：６７１．８５±２７６．９９，Ｂ级：２３２２．８９±１２９６．９５，Ｃ级：３３０８．６７±８３５．５７。经方差检验，Ａ、Ｂ、Ｃ三组间血清ＨＡ和ＣＧ浓度差异均有显著性（Ｆ＝２７．５３，Ｐ＜０．０００１；Ｆ＝４６．２１，Ｐ＜０．０００１）。以ＨＡ和ＣＧ联合考察早期肝硬化ｃｈｉｌｄＡ级３０例病人，假阴性率为２０．０％（６／３０），而常规白蛋白（ａｌｂｕｍｉｎ，Ａ）、总胆红素（ｔｏｔａｌｂｉｌｉｒｕｂｉｎ，ＴＢ）和凝血酶原时间（ｐｒｏｔｈｒｏｍｂｉｎｔｉｍｅ，ＰＴ）三项联合检测假阴性率为４６．７％（１４／３０）?
Objective To investigate the clinical significance of the combined detection of serum hyaluronic acid (HA) and cholylglycine (CG) in judging the progress and prognosis of cirrhosis and improving the positive rate of diagnosis of early cirrhosis. Methods One hundred and seventy patients with posthepatitic cirrhosis were divided into three groups according to child classification: A, B and C. The serum HA and CG in cirrhotic patients were detected by radioimmunoassay. The measurement data were tested for variance and the count data were analyzed by Chi-square test. Results Serum HA (ng / ml), childA grade: 262.15 ± 236.02, grade B: 498.42 ± 185.74, grade C: 609.89 ± 141.87; serum CG value ), ChildA grade: 671.85 ± 276.99, grade B: 2322.89 ± 1296.95, grade C: 3308.67 ± 835.57. After variance test, there was significant difference of serum HA and CG concentrations between A, B and C groups (F = 27.53, P <0.0001; F = 46.21, P <0.0001). The false negative rate was 20.0% (6/30) in HA and CG combined with childA grade of 30 patients with early cirrhosis, while albumin (A), total bilirubin (TB) and coagulation Prostrombintime (PT) three joint detection of false negative rate was 46.7% (14/30)?