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急性T淋巴细胞白血病(T-ALL)是进行性的血液系统恶性疾病,以T细胞克隆增生、积聚和组织浸润为特点,好发于儿童和青少年,占儿童急性淋巴细胞白血病的10%~15%。NOTCH1和磷脂酰肌醇3-激酶/丝氨酸/苏氨酸蛋白激酶(PI3K-Akt)信号通路及两者之间通过下游靶基因和靶蛋白实现的交互作用在T-ALL发生和发展中扮演重要角色。随着对这两条信号通路的认识逐渐深入,NOTCH1和PI3K-Akt信号通路成为治疗T-ALL的新靶点。
Acute T-lymphoblastic leukemia (T-ALL) is a progressive malignant disease of the hematological system characterized by hyperplasia, accumulation and tissue infiltration of T-cell clones, occurring in children and adolescents, accounting for 10% to 15% of childhood acute lymphoblastic leukemia %. The interaction between NOTCH1 and the phosphatidylinositol 3-kinase / serine / threonine protein kinase (PI3K-Akt) signaling pathway and their interaction with downstream target and target proteins plays an important role in the development and progression of T-ALL Character. With the deepening of understanding of these two signaling pathways, NOTCH1 and PI3K-Akt signaling pathways become new targets for the treatment of T-ALL.