G3BP(RasGAP SH3domain binding protein)是一种RasGAP SH3结构域特异性结合蛋白,参与Ras下游信号通路,属于RNA结合蛋白家族。G3BP具有核酸内切酶、DNA解旋酶活性,能够诱导应急颗粒的形成,参与多种细胞生长、分化、凋亡和RNA代谢的信号通路。已经发现G3BP在多种肿瘤组织和细胞中高表达,并且与侵袭转移相关。由于G3BP与肿瘤细胞的多种生物学特性有关,因此G3BP有望成为一个肿瘤治疗的新靶点。 G3BP (RasGAP SH3domain binding protein) is a RasGAP SH3 domain-specific binding protein that participates in the Ras downstream signaling pathway and belongs to the RNA binding protein family. G3BP has endonuclease and DNA helicase activities, can induce the formation of emergency particles, and is involved in various cell signaling pathways, such as cell growth, differentiation, apoptosis and RNA metabolism. G3BP has been found to be highly expressed in a variety of tumor tissues and cells, and is associated with invasion and metastasis. G3BP is expected to become a new target for oncology treatment due to the diverse biological characteristics of G3BP and tumor cells.