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目的和方法：观察脑腹中隔精氨酸加压素（ＡＶＰ）在α－黑素细胞刺激素（α－ＭＳＨ）解热机制中的作用；用放射免疫法测定ＡＶＰ含量。结果：ＥＧＴＡ引起明显的发热反应（Ｐ＜０．０１），同时降低脑腹中隔ＡＶＰ含量（Ｐ＜０．０５）。α－ＭＳＨ可抑制ＥＧＴＡ性发热反应（Ｐ＜０．０１），并增加脑腹中隔ＡＶＰ含量（Ｐ＜０．０５）；而对正常家兔体温及脑腹中隔ＡＶＰ含量无影响（Ｐ＞０．０５）。结论：α－ＭＳＨ对ＥＧＴＡ的解热作用可能部分是通过增加脑腹中隔ＡＶＰ的释放而实现的。在限制发热的过程中，内生解热物α－ＭＳＨ与ＡＶＰ可能具有协同作用。
PURPOSE AND METHODS: The effects of AVP on the antipyretic mechanism of α-melanocyte stimulating hormone (α-MSH) were observed. The content of AVP was determined by radioimmunoassay. Results: EGTA caused a significant fever response (P <0.01), meanwhile decreased AVP content in the ventral septum (P <0.05). α-MSH could inhibit the febrile response to EGTA (P <0.01) and increase the content of AVP in the ventral septum (P <0.05), but had no effect on the body temperature and the AVP level in the ventral septum > 0.05). CONCLUSION: The antipyretic effect of α-MSH on EGTA may be partially achieved by increasing the release of AVP in the ventral septum. Endothermic heatsome α-MSH may have a synergistic effect with AVP in limiting fever.