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目的研究小剂量琥珀胆碱(Scc)在全麻诱导气管插管中的作用及副作用。方法选择临床30例ASAⅠ~Ⅱ级的择期手术病人,在全麻诱导中应用不同剂量(15mg/kg和05mg/kg)的Scc,观察心血管系统、肌松作用、不良反应和并发症的变化。结果小剂量起效晚约216分钟,呼吸暂停时间短约209分钟,肌松作用及插管条件满意,对心血管系统的影响与大剂量相比无统计学差异,肌颤及术后肌病的发生亦无统计学差异(P>005)。结论与大剂量相比,小剂量也能提供满意的插管条件及充足的插管时间,不良反应及并发症并未相应减轻。
Objective To study the effects and side effects of low-dose succinylcholine (Scc) in tracheal intubation induced by general anesthesia. Methods Thirty ASA Ⅰ ~ Ⅱ clinical patients undergoing elective surgery were enrolled in this study. Scc at different doses (15 mg / kg and 05 mg / kg) were induced during general anesthesia. The effects of cardiovascular system, muscle relaxants, adverse reactions and Complications change. Results The onset of low dose was about 216 minutes late and the apnea time was about 209 minutes. The condition of muscle relaxation and intubation were satisfactory. The effect on cardiovascular system was not statistically different from that of high dose. Postoperative myopathy did not show any significant difference (P> 005). Conclusion Compared with the high dose, small dose can also provide satisfactory conditions for intubation and adequate intubation time, adverse reactions and complications did not reduce accordingly.