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目的:探讨葡萄糖转运蛋白1(GLUT1)和胰岛素样生长因子-Ⅰ(IGF-Ⅰ)表达与食管癌发生、发展的关系。方法:应用免疫组化SP法检测60例食管鳞癌及其癌旁不典型增生组织、正常食管黏膜组织中GLUT1和IGF-Ⅰ的表达。结果:上述3种组织中GLUT1的阳性表达率分别为91.67%、58.82%和20.00%,差异有统计学意义(P<0.05)。上述3种组织中IGF-Ⅰ的阳性表达率分别为75.00%、44.12%和0.00%,差异有统计学意义(P<0.05)。结论:GLUT1和IGF-Ⅰ蛋白的过表达可能共同参与了食管鳞癌的发生、发展。
Objective: To investigate the relationship between the expression of glucose transporter 1 (GLUT1) and insulin-like growth factor-Ⅰ (IGF-Ⅰ) and the occurrence and development of esophageal cancer. Methods: Immunohistochemical SP method was used to detect the expression of GLUT1 and IGF-Ⅰ in 60 cases of esophageal squamous cell carcinoma and its adjacent atypical hyperplasia and normal esophageal mucosa. Results: The positive rates of GLUT1 expression in the above three tissues were 91.67%, 58.82% and 20.00%, respectively, with significant difference (P <0.05). The positive rates of IGF-Ⅰ in the three tissues were 75.00%, 44.12% and 0.00%, respectively, with statistical significance (P <0.05). Conclusion: Overexpression of GLUT1 and IGF-Ⅰ protein may participate in the occurrence and development of esophageal squamous cell carcinoma.