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目的了解广州市人感染恙虫病东方体基因型的分布及特点。方法收集2012~2013年广州市恙虫病临床诊断病人全血,测定型特异性抗原基因部分序列,并进行基因序列同源性及系统进化分析。结果 133份标本中检测到40份阳性,其中Karp型21株,Kato型10株,Gilliam型5株,TA763型3株,未知型别1株。同源性分析显示其传播来源可能与台湾、日本、泰国等有关。结论广州市恙虫病东方体流行型别具多样性,来源复杂,开展更多分子流行病学研究将有助于其防控。
Objective To understand the distribution and characteristics of oriental genotypes of human tsutsugamushi disease in Guangzhou. Methods The whole blood and the specific sequence of the specific antigen gene in patients diagnosed as tsutsugamushi disease in Guangzhou from 2012 to 2013 were collected and analyzed for homology and phylogenetic analysis. Results A total of 40 positive samples were detected in 133 samples. Among them, 21 were Karp, 10 were Kato, 5 were Gilliam, 3 were TA763 and 1 was unknown. Homology analysis shows that the sources of its transmission may be related to Taiwan, Japan and Thailand. Conclusion The prevalence of oriental tsutsugamushi in Guangzhou is diverse and its origin is complex. To carry out more molecular epidemiological studies will help prevent and control it.