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观察在放射治疗鼻咽癌时血卟啉衍生物（hematoporphyrinderivative，HPD）对患者免疫功能的影响，选择病理确诊的初诊鼻咽癌78例，分成单纯放疗组和血卟啉衍生物（HPD）＋放疗组，各39例，采用自身配对方法，分别测定各组放疗前、后免疫功能。结果为：①HPD＋放疗组放疗前后免疫功能无明显变化；②单纯放疗组放疗后较放疗前免疫功能明显下降，包括OKT3、OKT4、OKT4／OKT8和淋巴细胞转化率均具有统计学意义（P＜0．01和P＜0．05）。上述结果提示HPD配合放射治疗鼻咽癌对免疫功能具有一定的保护作用。
To observe the effect of hematoporphyrinderivative (HPD) on the immune function in patients with nasopharyngeal carcinoma (NPC) treated by radiotherapy, 78 nasopharyngeal carcinomas newly diagnosed by pathology were divided into radiotherapy group and hematoporphyrin derivative (HPD) + Radiotherapy group, each 39 cases, using their own pairing method, were measured before and after radiotherapy in each group immune function. The results were as follows: ① There was no significant difference in immune function before and after radiotherapy in HPD + radiotherapy group. ② The immune function in radiotherapy group was significantly lower than that before radiotherapy, including OKT3, OKT4, OKT4 / OKT8 and lymphocyte transformation rate .01 and P <0.05). The above results suggest that HPD combined with radiation treatment of nasopharyngeal carcinoma on immune function has a certain protective effect.