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近年来应用一氧化氮吸入疗法(iNO)治疗各种原因引起的新生儿持续性肺动脉高压(PPHN)逐渐增多。iNO疗法用于足月或接近足月婴儿的经验较丰富。近来也有文献报道可用于呼吸窘迫综合征和脓毒血症引起的肺动脉高压的早产儿。在离体试验中iNO能够抑制血小板聚集,在成人和兔治疗中能使出血时间显著延长。此实验验证这一假说:在患有持续性肺动脉高压的足月新生
In recent years, the application of nitric oxide inhalation therapy (iNO) treatment of various causes of neonatal persistent pulmonary hypertension (PPHN) increased gradually. iNO therapy for the full-term or near full-term experience of infants more abundant. Recently, there are also reports in the literature of preterm infants that can be used for respiratory distress syndrome and pulmonary hypertension caused by sepsis. INO inhibits platelet aggregation in vitro and significantly prolongs bleeding time in adults and rabbits. This experiment validates this hypothesis: full term neonates with persistent pulmonary hypertension