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非甾体抗炎药都能抑制引起急性炎症的环氧合酶,有些还能抑制与慢性炎症有关的脂氧合酶。氟比洛芬(Flurbiprofen)能限制上述二酶,但对脂氧合酶作用很小。药理动物和临床研究证明,本品效力强、耐受良好,口服后胃肠吸收迅速,1小时达峰浓度。中间血浆终末半衰期(Interme-diate plasma terminal half-life)为5.52+1.4小时,与口服量无关。吸收后,99％结合于血清白蛋白Ⅱ型结合部位。24时尿中排出
Non-steroidal anti-inflammatory drugs can inhibit the cyclooxygenase that causes acute inflammation, and some can inhibit lipoxygenase associated with chronic inflammation. Flurbiprofen limits these two enzymes, but has little effect on lipoxygenase. Pharmacological and clinical studies have shown that this product is effective and well tolerated after oral administration of gastrointestinal absorption rapidly, peak concentration of 1 hour. Interme-diate plasma terminal half-life was 5.52 + 1.4 hours, irrespective of oral dose. After absorption, 99% binds to the serum albumin type II binding site. Excretion of urine in 24 hours